IGF-1 LR3 1MG

IGF-1 LR3 stands for insulin-like growth factor-1 long arginine 3. It is a man-made peptide derivative of insulin-like growth factor-1. It differs from IGF-1 by additional 13 amino acids at the N-terminus and the substitution of arginine with glutamic acid at the 3rd position. These modifications make it approximately 3 times more potent and extend its half-life (20-30 hours) and duration of action. Like IGF-1, it has been shown to promote muscle growth and cell differentiation. At Pinnacle Peptides, IGF-1 LR3 for sale is exclusively available for research and educational purchases.

IGF-1 LR3 retains the pharmacological properties of IGF-1 and binds to insulin-like growth factor-1 receptor. This binding triggers the cascade of intracellular events that eventually lead to the activation of the PI3/AKT and MAPT pathways. Activation of these pathways mediates various cellular responses, including protein synthesis, cell differentiation and proliferation in muscle and other cells.

Furthermore, IGF-1 LR3 has been shown to inhibit apoptosis. It is important to note that modifications in IGF-1 LR3 contribute to its low affinity to insulin-like growth factor binding proteins (IGFBP), extending its half-life.